October 2006 The presence of increased activated and degranulating mast cells in deeply infiltrating endometriosis, which are the most painful lesions, and the close histological relationship between mast cells and nerves strongly suggest that mast cells could contribute to the development of pain and hyperalgesia in endometriosis, possibly by a direct effect on nerve structures. […]

October 2006 This prospective clinical trial shows that women without significant decrease in pain after complete surgical excision of endometriosis should be considered for MRI to ascertain whether adenomyosis might be the actual cause of pain. Fifty-three women with chronic pelvic pain underwent pre-operative MR imaging to measure uterine JZ thickness, surgical excision, and pathologic […]

October 2006 Researchers in Australia have identified more nerve fibres in peritoneal endometriotic lesions than in normal peritoneum Peritoneal endometriotic lesions and normal peritoneum were prepared from women with and without endometriosis (n = 40 and 36, respectively). Specimens were also prepared from endosalpingiosis lesions (n = 9). These sections were stained immunohistochemically with antibodies […]

September 2006 Researchers reveal that many endometriosis patients, particularly those with concomitant adenomyosis, have their uterotubal transport impeded by hyperperistalsis or dysperistalsis Stefan Kissler, who led the research team at the Johann-Wolfgang-Goethe University at Frankfurt-am-Mainn in Germany, explains that the extent of the adenomyotic component in women with endometriosis explains much of the reduced fertility […]

July 2006 Research on mice, published in Human Reproduction, has led a team from the Catholic University of Louvain to conclude that an overload of iron in the pelvic cavity, while not causing the condition, may make the lesions grow by promoting the proliferation of their epithelial (lining) cells. Belgian fertility experts believe this may […]