Research and treatments

Latest news on clinical and scientific research in endometriosis.


HLA I expression raised in endometriosis
15 February 2006

February 2006 Researchers in Barcelona suggest that expression of class I human leukocyte antigen (HLA I) is significantly higher in endometrial samples from patients with endometriosis than in those from other people. In a cross sectional study, 32 patients who underwent an operation were diagnosed as having only endometriosis were enrolled, alongside a control group […]

Pre-IVF GnRH agonists boost pregnancy rates for endometriosis patients
15 February 2006

February 2006 A Cochrane review has found that endometriosis patients who use gonadotropin-releasing hormone (GnRH) agonists in the run-up to IVF have improved outcomes. In a systematic review of the existing literature, reviewers, led by Professor Hassan Sallam, from Alexandria University in Egypt, found that giving GnRH agonists to women with endometriosis for 3-6 months […]

Treatment of symptomatic rectovaginal endometriosis with an oestrogen-progestogen combination versus low-dose norethindrone acetate
15 November 2005

November 2005 Scientists in Italy have demonstrated that low-dose norethindrone acetate could be considered an effective, tolerable, and inexpensive first-choice medical alternative to repeat surgery for treating symptomatic rectovaginal endometrioti lesions in patients who do not seek conception. In order to evaluate the efficacy, safety and tolerability of an oestrogen-progestogen combination versus low-dose norethindrone acetate, […]

Endometriosis severity affects IVF outcome
15 November 2005

November 2005 Women with moderate-to-severe endometriosis are less likely to fall pregnant and have a baby with the help of IVF than those with minimal-to-mild disease, researchers have shown, according to Finish researchers. “Women with endometriosis often need IVF to conceive—most women need several cycles of treatment,” note the researchers, led by Paula Kuivasaari from […]

Infertility researchers identify one gene’s critical role in the human embryo implantation process
15 October 2005

October 2005 Researchers at Cedars-Sinai Medical Center and the University of California at Los Angeles recently conducted a study of the molecular mechanism involved in the human implantation process, specifically targeting the role of one gene in the success of an embryo to implant itself in the endometrium, the inner lining of the uterus. “There […]

Endostatin is a promising non-toxic endometriosis treatment
15 October 2005

October 2005 Antiangiogenic therapy with endostatin may present a promising novel, non-toxic therapeutic option for patients with endometriosis. Researchers at the Department of Surgery, Children’s Hospital, Harvard Medical School in Boston, USA, have shown that an anti-angiogenic protein hinders the development of endometriosis in mice without any apparent negative effects on fertility or reproduction. As […]

Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26
15 August 2005

August 2005 Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26 The cause of endometriosis remains uncertain despite >50 years of hypothesis-driven research, and thus the therapeutic options are limited. Disease predisposition is inherited as a complex genetic trait, which provides an alternative route to […]

A review of the use of lipiodol flushing for unexplained infertility
15 August 2005

August 2005 There has been speculation for decades regarding the role of flushing women’s fallopian tubes in improving the chance of pregnancy. More recent evidence has highlighted a possible specific role for lipiodol (ethiodized oil), an oil-soluble contrast medium, in the enhancement of fertility by these means. Nei Johnson, MD, of University of Auckland and […]

New study sheds light on endometriosis pain
15 June 2005

June 2005 New science suggests that women with endometriosis often have several types of pain conditions because their abnormal growths develop a nerve supply that communicates with the brain. Professor Karen Berkley from Florida State University is the lead researcher in a study that shows that endometrial cysts become supplied by sympathetic and sensory nerves […]

Vitamin E may relieve menstrual pain
15 April 2005

April 2005 Researchers in Iran have evaluated the efficacy of vitamin E for the treatment of primary dysmenorrhea (pelvic pain around the time of menstruation). This randomised, double-blind, placebo-controlled trial was published in the British Journal of Obstetrics and Gynaecology [1], and showed that adolescents with menstrual pain, who took vitamin E for 5 days […]

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