Research and treatments

Latest news on clinical and scientific research in endometriosis.

Progesterone receptor gene alleles linked with endometriosis risk
15 January 2007

January 2007 Women who carry the progesterone receptor (PR) gene allele +331A appear to have a reduced risk for deep infiltrating endometriosis compared with other women K van Kaam and team from the University of Maastricht set out to determine the frequencies of progesterone receptor gene polymorphisms in women with deep infiltrating endometriosis because alterations […]

Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15
15 December 2006

December 2006 Research published in Human Reproduction by the collaborative International Endogene Study suggests that there may be one or more high-penetrance susceptibility loci for endometriosis with (near-)Mendelian inheritance. The collaborative International Endogene Study consists of two data sets (Oxford and Australia) comprising 1176 families with multiple affecteds. The aim of the research team was […]

Nutrition plays a role in reproductive health
15 December 2006

December 2006 At the 62nd Annual Meeting of the ASRM several new studies were highlighted for the impact nutrition has on the reproductive system Dian Shepperson Mills presented how nutritional therapy provides an effective method of improving fertility rates and reducing abdominal pain in women with endometriosis. She promotes an integrated medical approach to improve […]

Improved visualisation of endometriosis using a new spectral analysis autoflourescence laparoscopy system: a pilot study
15 November 2006

November 2006 First prize for technical achievement was awarded to Dr Steven Palter at the 62nd annual meeting of the ASRM for a new surgery technique that enables surgeons to see tumours and other pathologies invisible with previous methods. Illumination of certain tissues with specific light wavelengths results in autoflourescence of the tissue, which can […]

Endometriosis may be generated by mimicking the ontogenetic development of the female genital tract.
15 November 2006

November 2006 Researchers at Johann Wolfgang Goethe-University in Frankfurt, Germany, suggest that endometriosis can arise through metaplasia The team set out to compare the expression of genes playing a decisive role during the embryonic development of the female genital tract (WNT4, WNT5A, WNT7A, PAX8) in the peritoneum of patients with endometriosis and control patients. An […]

Effects of different stages of endometriosis on the outcome of in vitro fertilization
15 November 2006

November 2006 Researchers at McGill University in Montreal, Canada, suggest that the presence of endometriosis, including stages III and IV, does not affect IVF outcome. This study was retrospective, with matched case-controls, set in an academic tertiary referral centre. The study group consisted of 87 women with laparoscopically diagnosed endometriosis, and the control group consisted […]

Mast cells may contribute to the development of pain and hyperalgesia in endometriosis
15 October 2006

October 2006 The presence of increased activated and degranulating mast cells in deeply infiltrating endometriosis, which are the most painful lesions, and the close histological relationship between mast cells and nerves strongly suggest that mast cells could contribute to the development of pain and hyperalgesia in endometriosis, possibly by a direct effect on nerve structures. […]

Persistence of dysmenorrhea and non-menstrual pain after optimal endometriosis surgery may indicate adenomyosis
15 October 2006

October 2006 This prospective clinical trial shows that women without significant decrease in pain after complete surgical excision of endometriosis should be considered for MRI to ascertain whether adenomyosis might be the actual cause of pain. Fifty-three women with chronic pelvic pain underwent pre-operative MR imaging to measure uterine JZ thickness, surgical excision, and pathologic […]

Nerve fibres may play an important role in the mechanisms of pain generation in endometriosis
15 October 2006

October 2006 Researchers in Australia have identified more nerve fibres in peritoneal endometriotic lesions than in normal peritoneum Peritoneal endometriotic lesions and normal peritoneum were prepared from women with and without endometriosis (n = 40 and 36, respectively). Specimens were also prepared from endosalpingiosis lesions (n = 9). These sections were stained immunohistochemically with antibodies […]

Adenomyosis predicts impaired uterotubal transport in endometriosis
15 September 2006

September 2006 Researchers reveal that many endometriosis patients, particularly those with concomitant adenomyosis, have their uterotubal transport impeded by hyperperistalsis or dysperistalsis Stefan Kissler, who led the research team at the Johann-Wolfgang-Goethe University at Frankfurt-am-Mainn in Germany, explains that the extent of the adenomyotic component in women with endometriosis explains much of the reduced fertility […]

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