Trial to determine the effectiveness of surgery for endometriosis

If you are undergoing a diagnostic laparoscopy for the investigation of chronic pelvic pain and have not previously had endometriosis diagnosed during surgery, you may be able to help with the ESPriT2 study.

Why is this study needed?

At the moment, there is no strong evidence that surgery to remove superficial peritoneal endometriosis (SPE; the commonest type of endometriosis) improves painful symptoms and quality of life.

This study will help to determine whether removing SPE improves painful symptoms and quality of life, which surgical approach may be best (ablation or excision), or whether surgery is of no benefit, worsens symptoms, or even causes harm.

To take part in this study you need to be

  • Aged over 16
  • Undergoing a laparoscopy for suspected endometriosis (and have no previous surgical diagnosis of endometriosis)

What does the study involve?

  • If only SPE is found during your diagnostic laparoscopy, you will be randomly allocated to one of two groups: one group will receive a diagnosis and have the endometriosis removed, while the other group will receive a diagnosis only. Both groups will have access to available hormonal and painkiller medications for endometriosis.
  • You will be asked to complete pain, symptom, and quality of life questionnaires before and after the surgery.

By taking part in this study, you will be helping us move closer to finding out whether or not surgical management of SPE improves pain and quality of life.


  • In addition to the main ESPriT2 study, you can also decide to take part in an additional sub-study named ESPriT+. Currently SPE can only be diagnosed by having a laparoscopy. We would like to see if we can use a blood test to tell us if women have endometriosis.
  • You can choose to take part in the main study without taking part in ESPriT+ and this would involve donating some blood.

How to get involved

If you would like to find out more about the ESPriT2 study please visit our website, and check out which centres near you are enrolling patients in the study.

These centres are currently enrolling patients for ESPriT2


  • NHS Ayrshire and Arran
  • NHS Fife
  • NHS Forth Valley
  • NHS Grampian
  • NHS Greater Glasgow and Clyde
  • NHS Highland
  • NHS Lanarkshire
  • NHS Lothian
  • NHS Tayside


  • Barkering, Havering and Redbridge University Hospitals NHS Trust
  • Barnsley Hospital NHS Foundation Trust
  • Birmingham Women’s and Children’s NHS Foundation Trust
  • Buckinghamshire Healthcare NHS Trust
  • Countess of Chester Hospital NHS Foundation Trust
  • East Lancashire Hospitals NHS Trust
  • Guy’s and St Thomas’ NHS Foundation Trust
  • Homerton University Hospital Foundation Trust
  • Milton Keynes University Hospital NHS Foundation Trust
  • Norfolk and Norwich University Hospitals NHS Foundation Trust
  • North Devon Healthcare NHS Trust
  • North Tees and Hartlepool NHS Foundation Trust
  • Oxford University Hospitals NHS Foundation Trust
  • Portsmouth Hospitals University NHS Trust
  • Royal Cornwall Hospitals NHS Trust
  • Royal Free London NHS Foundation Trust
  • Shrewsbury and Telford Hospitals NHS Trust
  • South Tees Hospitals NHS Foundation Trust
  • South Tyneside and Sunderland NHS Foundation Trust
  • Tameside and Glossop Integrated Care NHS Foundation Trust
  • The Rotherham NHS Foundation Trust
  • University College London Hospitals NHS Foundation Trust
  • University Hospitals of Leicester NHS Trust
  • University Hospital Southampton NHS Foundation Trust
  • Yeovil District Hospital NHS Foundation Trust

If you wish to contact a centre directly, please click here for their contact details
Click here if you are a clinician and interested in being a site for the ESPriT2 trial

See also

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