October 2006 The presence of increased activated and degranulating mast cells in deeply infiltrating endometriosis, which are the most painful lesions, and the close histological relationship between mast cells and nerves strongly suggest that mast cells could contribute to the development of pain and hyperalgesia in endometriosis, possibly by a direct effect on nerve structures. […]

October 2006 This prospective clinical trial shows that women without significant decrease in pain after complete surgical excision of endometriosis should be considered for MRI to ascertain whether adenomyosis might be the actual cause of pain. Fifty-three women with chronic pelvic pain underwent pre-operative MR imaging to measure uterine JZ thickness, surgical excision, and pathologic […]

October 2006 Researchers in Australia have identified more nerve fibres in peritoneal endometriotic lesions than in normal peritoneum Peritoneal endometriotic lesions and normal peritoneum were prepared from women with and without endometriosis (n = 40 and 36, respectively). Specimens were also prepared from endosalpingiosis lesions (n = 9). These sections were stained immunohistochemically with antibodies […]