Endometriosis Awareness Promotion Project (EAPP): a multi-national and multi-centre epidemiological study

The Endometriosis Awareness Promotion Project (EAPP) is a multinational and multi-center epidemiological study which, over three years (April 2022-March 2025), will investigate the fundamental concepts on menstrual pain (cyclic/acyclic) and endometriosis, its personal/social impact and effect of education on improving it among young women based on self-reported questionnaires.

This is an extended programme of the previous EAPP study that used medical and nursing students as the study population and is already completed and the results published in RBMO [1].

Professor Khaleque Khan (project coordinator and principal investigator) cordially invites collaborators from national/public/private medical universities and/or institutions to be part of this extended school-based study – see below how to contribute.


  1. To investigate the fundamental concepts on menstrual pain (cyclic/acyclic) and endometriosis, its personal/social impact and effect of education on improving it.
  2. To detect high-risk groups who are like to develop endometriosis with careful analysis of demographic profiles of participants.

Study population to participate in this study

  • Junior school and senior (high) school students
  • College students


  1. EAPP-part I: well-designed structured questionnaires to understand the fundamental concepts of menstrual pain and endometriosis. A separate set of questionnaires will be used to evaluate the effect of education before and 1-3 months after group discussion and/or lectures.
  2. EAPP-part II: well-designed structured questionnaires to investigate the pattern and severity of cyclic/acyclic pain, its personal/social impact, usefulness of medication, and demographic profiles of all participants.
  3. Motivation to visit gynaecologist and to take an imaging examination (USG).

End points of the study

  1. To evaluate the effect of proper education on improving fundamental concepts on menstrual pain, its effect on daily life activity and the biology of endometriosis.
  2. To identify high-risk groups of young women who may harbour endometriosis.
  3. Early detection and management of endometriosis.

Participating centres


  • Kyoto Prefectural University of Medicine
  • Oita University
  • Ryukyu University
  • Tottori University
  • Hyogo University
  • Nippon Medical University
  • Tokyo Dental and Medical University.

Outside Japan

  • Bangladesh: OGSB Hospital, Dhaka / Dhaka Medical University Hospital
  • Vietnam: Hue University of Medicine and Pharmacy / Hanoi Obstetrics and Gynecology Hospital
  • China: Fudan University, Shanghai
  • Turkey: Istanbul Medical University / Acibadem University, Istanbul
  • Taiwan: National Cheng Kung University, Tainan
  • Lithuania: Vilnius Medical University, Vilnius
  • Iran: Shiraz Medical University, Shiraz / Endometriosis Research Center, Iran University of Medical Sciences, Tehran
  • Indonesia: Faculty of Medicine, University of Indonesia, Jakarta
  • Israel: The  Lady Davis Carmel Medical Center, Haifa
  • India: Safal Fertility Foundation & Bansal Hospital, Ahmedabad
  • Thailand: Ramathibodi Hospital, Mahidol University, Bangkok
  • Sri Lanka: Faculty of Medicine, University of Colombo, Colombo
  • Kazakhstan: National Medical University, Almaty

How to join and contribute to this study

A/Professor Khaleque Khan

A/Professor Khaleque Khan, MD, PhD (principal investigator)
Department of Obstetrics and Gynaecology
Centre for Quality Research and Development
International Academic Exchange Centre
Kyoto Prefectural University of Medicine,
Kyoto, Japan

This study has epidemiologic input/support from Professor Stacey Missmer, Mitchigan State University (USA).

  1. Khan K, et al. A targeted educational programme improves the awareness and fundamental knowledge on menstrual pain and endometriosis in young women: The Endometriosis Awareness Promotion Program (EAPP). Reprod Biomed Online 2022 [in press].
See also

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