The most commonly affected sites are the pelvic organs
and peritoneum, although other parts of the body such as the lungs are
occasionally affected. The extent of the disease varies from a few,
small lesions on otherwise normal pelvic organs to large, ovarian endometriotic
cysts (endometriomas). There can be extensive fibrosis in structures
such as the uterosacral ligaments and adhesion formation causing marked
distortion of pelvic anatomy. Disease severity is assessed by simply
describing the findings at surgery or quantitatively, using a classification
system such as the one developed by the American Society for Reproductive
Medicine (ASRM) (1997). There
is no correlation between such systems and the type or severity of pain
symptoms.
Endometriosis typically appears as superficial "powder
burn" or "gunshot" lesions on the ovaries, serosal surfaces
and peritoneum - black, dark-brown, or bluish puckered lesions, nodules
or small cysts containing old haemorrhage surrounded by a variable extent
of fibrosis. Atypical or "subtle" lesions are also common,
including red implants (petechial, vesicular, polypoid, hemorrhagic,
red flame-like) and serous or clear vesicles. Other appearances include
white plaques or scarring and yellow-brown peritoneal discoloration
of the peritoneum.
Endometriomas usually contain thick fluid like tar;
such cysts are often densely adherent to the peritoneum of the ovarian
fossa and the surrounding fibrosis may involve the tubes and bowel.
Deeply infiltrating endometriotic nodules extend more than 5mm beneath
the peritoneum and may involve the utero-sacral ligaments, vagina, bowel,
bladder or ureters. The depth of infiltration is related to the type
and severity of symptoms (Chapron
et al., 2003a; Koninckx
et al., 1991; Porpora et
al., 1999).
Supporting Documentation