Research and treatments

Latest news on clinical and scientific research in endometriosis.


Adenomyosis predicts impaired uterotubal transport in endometriosis
15 September 2006

September 2006 Researchers reveal that many endometriosis patients, particularly those with concomitant adenomyosis, have their uterotubal transport impeded by hyperperistalsis or dysperistalsis Stefan Kissler, who led the research team at the Johann-Wolfgang-Goethe University at Frankfurt-am-Mainn in Germany, explains that the extent of the adenomyotic component in women with endometriosis explains much of the reduced fertility […]

Overload of iron in the pelvic cavity may promote proliferation of endometriosis lesions’ epithelial cells
15 July 2006

July 2006 Research on mice, published in Human Reproduction, has led a team from the Catholic University of Louvain to conclude that an overload of iron in the pelvic cavity, while not causing the condition, may make the lesions grow by promoting the proliferation of their epithelial (lining) cells. Belgian fertility experts believe this may […]

Red hair gene not linked to endometriosis
15 June 2006

June 2006 Contrary to what has been suggested by some “cross-sectional” studies, red hair colour is not associated with a higher or lower risk of endometriosis, the results of a prospective study indicate. However, the association may be affected by fertility status. Previous reports have identified alterations in coagulation (clotting) and immune function among women […]

Surgery may improve endometriosis-related sub-fertility
15 June 2006

June 2006 IVF can be perceived as the last hope in achieving pregnancy, yet researchers at Stanford University have looked at patients with previous IVF failures who conceived following laparoscopic treatment for endometriosis. Out of 29 patients with prior IVF failures, 22 (76%) conceived following laparoscopic treatment of endometriosis, including non-IVF pregnancies and seven IVF […]

Activin-A secretion is increased in the eutopic endometrium from women with endometriosis
15 May 2006

May 2006 Researchers at Monash University in Melbourne, Australia, have concluded that the expression of inhibin/activin subunits in eutopic endometrium is altered in women with endometriosis, leading to higher levels of activin-A secretion by both glandular cells and stromal cells. Activin is a well-characterised growth and differentiation factor and an important inflammatory mediator. Activin is […]

Deficient intake of antioxidant molecules is related to peripheral and peritoneal oxidative stress in endometriosis
15 May 2006

May 2006 Researchers in Mexico have evaluated the antioxidant intake and the lipoperoxidation status in plasma and peritoneal fluid of women with endometriosis. They demonstrated that there was an inverse correlation with the pathology intensity depending on the antioxidant intake in women with endometriosis. As endometriosis severity intensifies there is less of an intake of […]

High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis
15 March 2006

March 2006 Researchers in Australia suggest that small nerve fibres detected in the functional layer in all women with endometriosis may have important implications for understanding why pain occurs in these patients. Tokushige et al prepared histological sections of endometrial tissue from endometrial curettings and hysterectomies performed on women with endometriosis (n=25 and n=10, respectively) […]

HLA I expression raised in endometriosis
15 February 2006

February 2006 Researchers in Barcelona suggest that expression of class I human leukocyte antigen (HLA I) is significantly higher in endometrial samples from patients with endometriosis than in those from other people. In a cross sectional study, 32 patients who underwent an operation were diagnosed as having only endometriosis were enrolled, alongside a control group […]

Pre-IVF GnRH agonists boost pregnancy rates for endometriosis patients
15 February 2006

February 2006 A Cochrane review has found that endometriosis patients who use gonadotropin-releasing hormone (GnRH) agonists in the run-up to IVF have improved outcomes. In a systematic review of the existing literature, reviewers, led by Professor Hassan Sallam, from Alexandria University in Egypt, found that giving GnRH agonists to women with endometriosis for 3-6 months […]

Treatment of symptomatic rectovaginal endometriosis with an oestrogen-progestogen combination versus low-dose norethindrone acetate
15 November 2005

November 2005 Scientists in Italy have demonstrated that low-dose norethindrone acetate could be considered an effective, tolerable, and inexpensive first-choice medical alternative to repeat surgery for treating symptomatic rectovaginal endometrioti lesions in patients who do not seek conception. In order to evaluate the efficacy, safety and tolerability of an oestrogen-progestogen combination versus low-dose norethindrone acetate, […]

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