Research and treatments

Latest news on clinical and scientific research in endometriosis.

Endometriosis may be generated by mimicking the ontogenetic development of the female genital tract.
15 November 2006

November 2006 Researchers at Johann Wolfgang Goethe-University in Frankfurt, Germany, suggest that endometriosis can arise through metaplasia The team set out to compare the expression of genes playing a decisive role during the embryonic development of the female genital tract (WNT4, WNT5A, WNT7A, PAX8) in the peritoneum of patients with endometriosis and control patients. An […]

Effects of different stages of endometriosis on the outcome of in vitro fertilization
15 November 2006

November 2006 Researchers at McGill University in Montreal, Canada, suggest that the presence of endometriosis, including stages III and IV, does not affect IVF outcome. This study was retrospective, with matched case-controls, set in an academic tertiary referral centre. The study group consisted of 87 women with laparoscopically diagnosed endometriosis, and the control group consisted […]

Mast cells may contribute to the development of pain and hyperalgesia in endometriosis
15 October 2006

October 2006 The presence of increased activated and degranulating mast cells in deeply infiltrating endometriosis, which are the most painful lesions, and the close histological relationship between mast cells and nerves strongly suggest that mast cells could contribute to the development of pain and hyperalgesia in endometriosis, possibly by a direct effect on nerve structures. […]

Persistence of dysmenorrhea and non-menstrual pain after optimal endometriosis surgery may indicate adenomyosis
15 October 2006

October 2006 This prospective clinical trial shows that women without significant decrease in pain after complete surgical excision of endometriosis should be considered for MRI to ascertain whether adenomyosis might be the actual cause of pain. Fifty-three women with chronic pelvic pain underwent pre-operative MR imaging to measure uterine JZ thickness, surgical excision, and pathologic […]

Nerve fibres may play an important role in the mechanisms of pain generation in endometriosis
15 October 2006

October 2006 Researchers in Australia have identified more nerve fibres in peritoneal endometriotic lesions than in normal peritoneum Peritoneal endometriotic lesions and normal peritoneum were prepared from women with and without endometriosis (n = 40 and 36, respectively). Specimens were also prepared from endosalpingiosis lesions (n = 9). These sections were stained immunohistochemically with antibodies […]

Adenomyosis predicts impaired uterotubal transport in endometriosis
15 September 2006

September 2006 Researchers reveal that many endometriosis patients, particularly those with concomitant adenomyosis, have their uterotubal transport impeded by hyperperistalsis or dysperistalsis Stefan Kissler, who led the research team at the Johann-Wolfgang-Goethe University at Frankfurt-am-Mainn in Germany, explains that the extent of the adenomyotic component in women with endometriosis explains much of the reduced fertility […]

Overload of iron in the pelvic cavity may promote proliferation of endometriosis lesions’ epithelial cells
15 July 2006

July 2006 Research on mice, published in Human Reproduction, has led a team from the Catholic University of Louvain to conclude that an overload of iron in the pelvic cavity, while not causing the condition, may make the lesions grow by promoting the proliferation of their epithelial (lining) cells. Belgian fertility experts believe this may […]

Red hair gene not linked to endometriosis
15 June 2006

June 2006 Contrary to what has been suggested by some “cross-sectional” studies, red hair colour is not associated with a higher or lower risk of endometriosis, the results of a prospective study indicate. However, the association may be affected by fertility status. Previous reports have identified alterations in coagulation (clotting) and immune function among women […]

Surgery may improve endometriosis-related sub-fertility
15 June 2006

June 2006 IVF can be perceived as the last hope in achieving pregnancy, yet researchers at Stanford University have looked at patients with previous IVF failures who conceived following laparoscopic treatment for endometriosis. Out of 29 patients with prior IVF failures, 22 (76%) conceived following laparoscopic treatment of endometriosis, including non-IVF pregnancies and seven IVF […]

Activin-A secretion is increased in the eutopic endometrium from women with endometriosis
15 May 2006

May 2006 Researchers at Monash University in Melbourne, Australia, have concluded that the expression of inhibin/activin subunits in eutopic endometrium is altered in women with endometriosis, leading to higher levels of activin-A secretion by both glandular cells and stromal cells. Activin is a well-characterised growth and differentiation factor and an important inflammatory mediator. Activin is […]

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