Are you due to have a laparoscopy for symptoms suggestive of endometriosis?

Many women with endometriosis are treated surgically, but symptoms can recur in just under half of them. Clinicians are uncertain about how best to prevent this.

endometriosis-PRE-EMTThirty two hospitals throughout the UK have joined a large national clinical trial to find out if long acting progestogen treatment (either Mirena Coil® or Depo-Provera®) is more effective compared to the oral contraceptive pill in preventing the recurrence of symptoms and improving quality of life.

The target population is women of reproductive age with laparoscopically diagnosed endometriosis, who have undergone conservative surgery for alleviation of pelvic pain, and who have no contraindications to any of the proposed hormonal treatments. The PRE-EMPT trial will be discussed with women when they are scheduled for laparoscopic surgery

The treatments offered in PRE-EMPT are:

You may be eligible to take part in the PRE-EMPT trial if you

  • are aged between 16-45 years;
  • have no immediate plans to conceive;
  • are scheduled to have laparoscopic conservative surgery, or a diagnostic laparoscopy with concurrent surgery if endometriosis is found, for pelvic pain associated with endometriosis;
  • are willing to be randomised to either:
    • one long acting progestogen (you can chose between Mirena® or Depo-provera®)OR
    • the combined oral contraceptive pill.

What the trial involves

We will collect information on your pain, physical, and emotional wellbeing at the beginning of the study. A similar questionnaire will then be sent to you at home at six months, and then at one, two, and three years after treatment. The questions are designed to find out if there are any improvements or changes in your symptoms following treatment.

Which hospitals are taking part

Aberdeen Royal Infirmary QMC – Nottingham Treatment Centre
Addenbrooke’s (Cambridge) Royal Albert Edward Infirmary
Arrowe Park Hospital Royal Berkshire Hospital
Basingstoke & North Hampshire Royal Infirmary of Edinburgh
Birmingham Women’s Hospital Royal Preston Hospital
Chelsea and Westminster Hospital Southend University Hospital
Chesterfield Royal Hospital St Mary’s, Manchester
Cumberland Infirmary & W. Cumberland Hospital St Peter’s Hospital
Furness General Hospital St Richard’s Hospital, Chichester
James Cook University Hospital Stoke Mandeville Hospital
John Radcliffe Hospital The Royal Victoria Infirmary (Newcastle)
Kings Mill Hospital University College London Hospital
Liverpool Women’s Hospital University Hospital Crosshouse
Milton Keynes Hospital University Hospital of North Durham
Peterborough City Hospital University Hospital of North Tees
Princess of Wales (Wales) Yeovil District Hospital

How to participate in the trial

If you are interested in participating in this trial, please contact:

Laura Gennard
Senior Trial Coordinator
t: +44 (0)121 415 9109
f: +44 (0)121 415 9136
Birmingham Clinical Trials Unit (BCTU)
Institute of Applied Health Research
Public Health Building
University of Birmingham
B15 2TT


Recommend, read later, or share this article

Stay up to date

Register for endometriosis news:

Get involved

Help us improve treatments for endometriosis and prevent this disease in the next generation of women. Support the work of the World Endometriosis Research Foundation.

Donate to research Shop for WERF Volunteer