Do you suffer from unexplained pelvic pain?

Eight UK endometriosis centres are running a clinical trial to find out if gabapentin reduces pelvic pain in women, where no cause for their pain has been found. They are also investigating whether the drug could improve these women’s quality of life.

Gabapentin is a drug originally developed to treat epilepsy. It has been found to be an effective painkiller for a specific type of pain (neuropathic) which affect the nerves. This may also help with chronic pelvic pain but as there if no evidence to prove this – we need to run a trial.

Half of the women in the trial will be given gabapentin and half will be given a dummy tablet; and we will compare the results at the end. No-one will know which treatment they are on until the end of the study. This is known as a double-blinded study.

You may be eligible to take part in the GaPP2 trial if you

  • are aged between 18-50 years
  • have suffered from chronic pelvic pain for more than 3 months
  • have had a laparoscopy in the past three years (>2 weeks but <36 months), which did not find any cause for your pain
  • are not planning a pregnancy in the next 6 months.

What the trial involves

We will collect information on your pain, physical and emotional wellbeing at the beginning of the study, and again after 12 weeks of taking the drugs. We will collect this by asking you to fill out different questionnaires.

We will ask 50 women (recruited in Edinburgh) to have a brain scan to help us further understand how gabapentin works.

Which hospitals are taking part

• Aberdeen Royal Infirmary

• Birmingham Women’s NHS Foundation Trust

• Edinburgh Royal Infirmary

• University Hospitals of Leicester NHS Trust

• University College London

• James Cook University Hospital, Middlesborough

• John Radcliffe Hospital, Oxford

• Southampton General Hospital

How to get involved

For more information about the hospitals recruiting and how to get in touch, please visit the trial website.


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