SCIENTIFIC PROGRAMME
Progesterone Resistance, Endometriosis, Pregnancy Loss and Fertility
Wednesday 21 October 2009 13.15-14.15
Faculty: Serdar Bulun and Steven Young
Optimal clinical management of fertility disorders in women with endometriosis remains uncertain due, in part, to large gaps in knowledge regarding the cellular and molecular basis for reproductive dysfunction in these women. Recently, it has been found that women with endometriosis display evidence of progesterone resistance, which has potential impact on disease formation and progression, as well as fertility and pregnancy maintenance. This session will highlight important concepts involving progesterone resistance in clinical practice.
Environment and Reproduction
Wednesday 21 October 15.45-17.45
Faculty: Linda Giudice, Russ Hauser, Tracey Wooddruff
Increasingly, scientific evidence indicates that a number of reproductive health endpoints and disorders—including infertility and subfertility, sperm count/semen quality decline, pregnancy loss, adverse birth outcomes, and reproductive tract abnormalities such as endometriosis—are associated with environmental contaminants that many Americans are exposed to in their daily lives. Practicing medical professionals often are not aware that the responses to environmental exposures can be sex-specific, develop at critical times of development and life stages, are dependent on dose and time of exposure, and can have transgenerational effects. The objective of this symposium is to present the current state of the science linking environmental contaminants with male and female reproductive health and fertility compromise. Presenters will also discuss critical research directions and approaches, and tools for informing patients about environmental contaminants and ways to avoid potentially harmful exposures. Course participants will learn about some of the key contaminants of concern, including phthalates, bisphenol A, and solvents, and how they have been implicated in reproductive and fertility effects.
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ORAL PRESENTATIONS
Monday 19 October 2009 16.15.18.00
O-33 ENDOMETRIOSIS AND AUTOIMMUNE DISEASE: ASSOCIATION OF SUSCEPTIBILITY WITH PTPN22. J. Sundqvist1, H. Falconer1, L. Padyukov2, A. Vodolazkaia3, K. Gemzell-Danielsson1, T. M. D´Hooghe3. 1Woman and Child Health, Karolinska Institutet, Stockholm, Sweden; 2Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden; 3Obstetrics and Gynecology, Leuven University, Leuven, Belgium.
O-34 EXPRESSION OF MATRIX METALLOPROTEINASE-7, E-CADHERIN AND BETA CATENIN IN ENDOMETRIOSIS: STRATEGIES FOR TREATMENT OF ENDOMETRIOSIS MIGHT DIFFER AMONG DIFFERENT FORMS OF ENDOMETRIOSIS. S. Matsuzaki1, E. Maleysson2, G. Mage1, M. Canis1. 1CHU Clermont-Ferrand, Polyclinique, Clermont-Ferrand, Auvergne, France; 2Université d’Auvergne-Clermont I, CENTI, Clermont-Ferrand, Auvergne, France.
O-35 APIGENIN INHIBITS TNFa-INDUCED CELL PROLIFERATION IN ENDOMETRIOTIC STROMAL CELLS. F. Taniguchi, Y. Tagashira, K. Suou, T. Iwabe, T. Harada. Ob & Gyn, Tottori University Faculty of Medicine, Yonago, Japan.
O-36 SELECTIVE INHIBITION OF PROSTAGLANDIN E2 SIGNALING INHIBITS MIGRATION AND INVASION OF HUMAN ENDOMETRIOTIC EPITHELIAL AND STROMAL CELLS THROUGH MULTIPLE MECHANISMS. J. A. Arosh1, J. Lee1, R. Rodrigues1, V. O. Speights2, A. Starzinski-Powitz3, S. K. Banu1. 1Department of Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX; 2Department of Pathlogy, Scott & White Memorial Hospital, Temple, TX; 3Molekulare Zellbiologie und Humangenetik, Institut für Zellbiologie und Neurowissenschaft, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.
O-37 THE EFFECT OF JNK-INHIBITORS ON ENDOMETRIOSIS IN BABOONS WITH INDUCED DISEASE: A PLACEBO-CONTROLLED RANDOMIZED STUDY. M. H. M. Yousef1, D. C. Chai2, J. M. Mwenda2, T. M. D’Hooghe3. 1Obstetrics and Gynecology, Woman’s Health Center, Assiut, Egypt; 2Reproductive Medicine, Institute of Primate Research, Nairobi, Karen, Kenya; 3Department of Obstetrics and Gynecology, Leuven University Fertility Center, Leuven, Belgium.
O-38 PROGESTERONE (P) RESISTANCE IN THE ENDOMETRIUM OF RHESUS MACAQUES WITH ADVANCED ENDOMETRIOSIS ATTENUATES LEVELS OF CYSTEINE RICH SECRETORY PROTEIN 3 (CRISP3). C. S. Keator, A. M. Lawson, K. Mah, O. D. Slayden. Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR.
O-39 PPAR-GAMMA LIGAND ACTIVATION DECREASES P450 AROMATASE GENE EXPRESSION IN HUMAN ENDOMETRIOTIC EPITHELIAL AND STROMAL CELLS IN VITRO. S. K. Kavoussi1, J. A. Arosh2, J. Lee2, S. K. Banu2, D. I. Lebovic3. 1Austin Endometriosis and Fertility Center, Austin, TX; 2Department of Integrative Biosciences, Reproductive Endocrinology and Cell Signaling Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX; 3Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The University of Wisconsin, Madison, WI.
O-40 HOXA10 IS EXPRESSED IN THE ENDOMETRIAL STROMA AND IN THE MUSCLE OF RECTOSIGMOID ENDOMETRIOSIS. A. Zanatta1, P. Serafini1,2, A. M. Rocha1, F. M. Carvalho2,3, E. C. Baracat2, H. Taylor4. 1Huntington Medicina Reprodutiva, São Paulo, Brazil; 2Disciplina de Ginecologia, Universidade de São Paulo, São Paulo, Brazil; 3Departamento de Patologia, Faculdade de Medicina - Universidade de São Paulo, São Paulo, Brazil; 4Division of Reproductive Endocrinology and Infertility - Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT.
The EndoSIG meeting is on Tuesday 20 October at 18.15-19.00
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